Description

Reversible protein phosphorylation is one of the key mechanisms for cell signaling. Protein Tyrosine Kinases serve as the ‘signaling currency’ of the cell, while Protein Tyrosine Phosphatases (PTPs) ensure homeostasis, which is critical to cell survival and growth. Their role is well established in neuronal development, growth and differentiation, glucose homeostasis, and immune response. Hence PTPs are of increasing importance for drug discovery.